Isabel Bondia-Pons

Isabel Bondia Pons
NNF Senior fellow
Systems Medicine

Phone: +45 30 91 29 26

Research area 
My research focuses on combining metabolomics research with nutritional and clinical intervention studies, aiming to develop novel biomarkers that would enable personalized intervention and disease prevention. During my last years of research, I have been focused in the field of Nutritional Metabolomics and Systems Biology, to elucidate how diet and other environmental factors affect the metabolome in obesity and metabolic syndrome. 

As a chemist, I am highly interested in (1) new advances in analytical methodology, especially in the field of mass spectrometry-based metabolomics analytics; and in (2) application of bioinformatic tools for data integration. I am particularly excited about translation of the metabolomics approach into the clinical practice. As a food technologist, I am interested in the identification of those metabolic pathways behind the maintenance of metabolic homeostasis, both in health and in metabolic disorders linked to dietary and lifestyle habits. 

I see metabolomics as a potential tool to influence diabetic patient care. I believe that a comprehensive metabolome/lipidome characterization of relevant tissues (such as adipose tissue, liver, and skeletal muscle) at different stages in progression to metabolic disease is currently needed in order to identify and understand the pathways behind the transition point from healthy status to initiation of co-morbidities in those non-communicable diseases, such as type 2 diabetes (T2D), that most affect individuals from both developed and developing countries. 

My current research is based on applying a metabolomics systems biology approach in well phenotyped participants of unique clinical studies to elucidate critical pathophysiologic mechanisms and ethiology of obesity and its co-morbidities, which special focus in T2DM and insulin resistance. My main interest is to (1) identify and understand the pathways behind the transition point from health to T2D, and (2) to identify novel circulating biomarkers sensitive to adipose tissue metabolite changes. The final aim is to find out and validate early predictive biomarkers of co-morbidities associated with obesity and T2D for future implementation in clinical diagnostics. 

Ongoing projects
Metabolome in obesity and its co-morbidities, with focus on insulin resistance and type 2-diabetes. Novo Nordisk Foundation Clinical Research (NNFCR) Fellow
EU FP7 DEXLIFE (Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression) -  Postdoctoral Fellow

2007 Ph.D. in Food Science & Technology, University of Barcelona, Spain
2002 M.Sc. in Chemistry (Chemical Engineering), University of Barcelona, Spain
2001 B.Sc. in Food Science & Technology, University of Barcelona, Spain
2000 B.Sc. in Chemistry, University of Barcelona, Spain

Latest positions
January 2015 –  , NNFCR Senior fellow, Systems Medicine, Steno Diabetes Center (Gentofte, Denmark)
Jul 2014 – Dec 2014, Postdoctoral fellow, Systems Medicine, Steno Diabetes Center (Gentofte, Denmark)
Jan 2012 – Dec 2013, Visiting Postdoctoral Research Associate (Sara-Borrell Contract), Unit of Metabolomics, VTT Technical Research Centre of Finland (Espoo, Finland)
Jan 2010 – Dec 2011, Postdoctoral Research Associate (Sara-Borrell Contract), Schools of Pharmacy and Science, Dept. of Nutrition, Food Science and Physiology, University of Navarra (Pamplona, Spain)
Oct 2007 – Dec 2009, Postdoctoral fellow, School of Medicine, Faculty of Health Sciences, Dept. of Clinical Nutrition, University of Eastern Finland (Kuopio, Finland)
Jan 2004 – Sept 2007, PhD student (F.P.U. Fellowship), Faculty of Pharmacy, Dept. of Nutrition & Food Sciences, University of Barcelona (Barcelona, Spain) 
Jun 2005 – Sept 2005, Visiting PhD student (Marie Curie Fellowship), Faculty of Food Science and Technology, Dept. of Food and Nutritional Sciences, University College Cork (Cork, Ireland)
Jan 2003 – Dec 2003, Graduate research assistant (Fundacio Bosch i Gimpera Contract), Faculty of Pharmacy, Dept. of Nutrition & Food Sciences, University of Barcelona (Barcelona, Spain) 

Positions of trust 
European Nutrition Leadership Programme ENLP; Member (2010- current)
Metabolomics Society; Member (2008 – current) 

Pilot plant level extraction of internal wool lipids (2nd prize to the Best Textile
Chemical Study of Applicability in the Industry, 16th A.E.Q.C.T. Award, 12th March  2003, Barcelona, Spain)

Presentations the last 4 years 

2013, International Conference on FoodOmics, Cesena, Italy
2012, NuGO week 2012 - Nutrition, lifestyle and genes in the changing environment, Helsinki, Finland
2012, Metabolomics 2012, Washington, DC, USA
2012, 19th European Congress of Obesity, Lyon, France
2011, Metabomeeting 2011, Helsinki, Finland
2011, Nutrigenomics in Clinical Interventions Course, Kuopio, Finland
2010, Metabolomics 2010, Amsterdam, The Netherlands
2010, Nutrigenomics and Metabolomics in Nutrition, The Royal National Academy of Pharmacy, Madrid, Spain.
2010, VIII International Conference on the Mediterranean Diet, Barcelona, Spain.

Scientific publications 
Google scholar profile 
Publications in Pubmed

Sidst opdateret 12-01-2017