Ismo Mattila

Ismo Mattila

Research Scientist
Systems Medicine

E-mail ismo.matias.mattila@regionh.dk
Phone +45 30 91 33 43

 

Research area
I have a strong background in analytical chemistry and mass spectrometry. I have analysed a wide variety of sample types, including clinical samples, plant samples and cell fermentations. I have also developed online mass spectrometric methods.

Currently I am responsible for GC×GC-TOFMS analysis and method development. The main application of the instrument is the global metabolomics method, which has been used extensively in diabetes research projects.

Ongoing projects
EU FP7 DEXLIFE (Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression) – Research Scientist.

Education 
1995 MSc, analytical chemistry, Helsinki University, Helsinki, Finland.

Latest positions
Research Scientist, VTT Technical Research Centre of Finland (Espoo, Finland),(1996 - 2014).

Scientific publications
Google scholar profile (publications, citations)
Publications in Pubmed

Selected publications (42 publications in total)
Bondia-Pons I, Maukonen J, Mattila I, Rissanen A, Saarela M, Kaprio J, Hakkarainen A, Lundbom J, Lundbom N, Hyötyläinen T, Pietiläinen KH, Orešič M. Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge. FASEB J. 2014. doi: 10.1096/fj.14-250167

Claudia Vetrani, Angela A Rivellese, Giovanni Annuzzi, Ismo Mattila, Emanuelle Meudec, Tuulia Hyötyläinen, Matej Orešič, Anna-Marja Aura. Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention. Food Research International 63, 233-238 (2014).

M. Orešič, T. Hyötyläinen, A. Kotronen, P. Gopalacharyulu, H. Nygren, J. Arola, S. Castillo, I. Mattila, A. Hakkarainen, R. J.H. Borra, M.-J. Honka, A. Verrijken, S. Francque, P. Iozzo, M. Leivonen, N. Jaser, A. Juuti, T. I. A. Sørensen, P. Nuutila, L. Van Gaal, H. Yki-Järvinen, Prediction of non-alcoholic fatty liver disease and liver fat content by serum molecular lipids, Diabetologia 56, 2266-2274 (2013).

Anna-Marja Aura, Ismo Mattila, Tuulia Hyötyläinen, Peddinti Gopalacharyulu, Veronique Cheynier, Jean-Marc Souquet, Magali Bes, Carine Le Bourvellec, Sylvain Guyot, Matej Orešič. Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches, Eur J Nutr 52, 833-846 (2012).

T. Hyötyläinen, I. Mattila, S. Wiedmer, A. Koivuniemi, M.-R. Taskinen, H. Yki-Järvinen, M. Orešič, Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance, Mol. Biosyst. 8, 2559-2565 (2012).

M. Orešič, T. Hyötyläinen, S.-K. Herukka, M. Sysi-Aho, I. Mattila, T. Seppänan-Laakso, V. Julkunen, P. V. Gopalacharyulu, M. Hallikainen, J. Koikkalainen, M. Kivipelto, S. Helisalmi, J. Lötjönen, H. Soininen, Metabolome in progression to Alzheimer’s disease, Transl. Psychiatry 1, e57 (2011). (Commentary in Alzheimer Research Forum) (Commentary in Neurology Today)

Sandra Castillo, Ismo Mattila, Jarkko Miettinen, Matej Orešič, Tuulia Hyötyläinen, Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry, Anal. Chem. 83, 3058-3067 (2011).

M. Sysi-Aho, A. Ermolov, P. V. Gopalacharyulu, A. Tripathi, T. Seppänen-Laakso, J. Maukonen, I. Mattila, S. T. Ruohonen, L. Vähätalo, L. Yetukuri, T. Härkönen, E. Lindfors, J. Nikkilä, J. Ilonen, O. Simell, M. Saarela, M. Knip, S. Kaski, E. Savontaus, M. Orešič, Metabolic regulation in progression to autoimmune diabetes, PLoS Comp. Biol. 7(10), e1002257 (2011).

M. Orešič, J. Tang, T. Seppänen-Laakso, I. Mattila, S. E. Saarni, S. I. Saarni, J. Lönnqvist, M. Sysi-Aho, T. Hyötyläinen, J. Perälä, J. Suvisaari, Metabolome in schizophrenia and other psychotic disorders: a general population-based study, Genome Med. 3, e19 (2011).

Anna-Marja Aura, Ismo Mattila, Tuulia Hyötyläinen, Peddinti Gopalacharyulu, Catherine Bounsaythip, Matej Orešič, Kirsi-Marja Oksman-Caldentey, Drug metabolome of the Simvastatin formed by human intestinal microbiota in vitro, Mol. BioSyst. 7, 437-446 (2010).

M. Orešič, S. Simell, M. Sysi-Aho, K. Näntö-Salonen, T. Seppänen-Laakso, V. Parikka, M. Katajamaa, A. Hekkala, I. Mattila, P. Keskinen, L. Yetukuri, A. Reinikainen, J. Lähde, T. Suortti, J. Hakalax, T. Simell, H. Hyöty, R. Veijola, J. Ilonen, R. Lahesmaa, M. Knip, O. Simell, Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes, J. Exp. Med. 205(13), 2975-2984 (2008).(commentary) (Faculty of 1000 Biology evaluation)

Sidst opdateret 12-01-2017