The Inter99 study

Background and aim
The Inter99 study was a non-pharmacological randomised intervention study, initiated by Torben Jørgensen, Knut Borch-Johnsen, Hans Ibsen, and Troels Thomsen.

The aim of the study was to assess the effect of a preventive strategy including individualised risk assessment; multifactorial, non-pharmacological intervention based on tailored information, motivation and support; and a programme for maintenance. 

Study design and intervention

A total of 6,784 men and women aged 30-60 years received a health screening, a personal risk assessment and a lifestyle counselling in 1999-2001.

Individuals pre-randomised to group A (high intensity intervention) and who were categorised as having high risk for developing IHD were furthermore offered lifestyle counselling in groups with six meetings during a 4-6 month period.

Individuals pre-randomised to group B (low intensity intervention) did not receive lifestyle counselling in groups, but were referred to their general practitioner. All individuals in group A and B belonging to the high-risk group was re-invited for a new assessment after 1 and 3 years. All 6,784 participants were invited to a re-examination after 5-years of follow-up.

Available data
Questionnaire data include:
  • Health (illness, medication history)
  • Lifestyle (diet, smoking, physical activity, socioeconomic characteristics)

Clinical data include:
  • Anthropometry (height, weight, waist, hip)
  • Blood analysis (fasting-, 30 min- and 2-hour glucose and insulin, biomarkers, lipids)
  • Blood pressure
  • Estimated risk of ischemic heart disease based on the PRECARD®  computer program

Responsible for the Inter99 study:
Professor Allan Linneberg
Rigshospitalet – Glostrup
Nordre Ringvej 57, afsnit 84-85
2600 Glostrup
Phone: +45 38 63 31 87

Our research group works in close collaboration with the Research Center for Prevention and Health. Researchers at Steno have published several research papers based on data collected as part of the Inter99 study.

Contact persons in Clinical Epidemiology: Marit Eika Jørgensen, Dorte Vistisen or Kristine Færch

Sidst opdateret 14-03-2016